A Novel Approach Combining Oncolytic Virotherapy and Dual Immune Checkpoint Blockade for Metastatic Osteosarcoma

Abstract

Osteosarcoma is one of the most common cancers of children and adolescents and young adults (AYAs). The outcomes for with metastatic osteosarcoma are especially dismal because there are no effective options to treat this condition. Our objectives are to tilt the immune landscape of metastatic osteosarcoma from immunosuppression to immunoreactivity, and to generate preclinical support to translate this innovative immunotherapy for the treatment of children and AYAs with metastatic bone cancer. To achieve this, we propose to combine an oncolytic virus, which will kill tumor cells and activate the immune system in the tumor environment, with a drug that blocks the myeloid checkpoint to enhance phagocytosis and antigen presentation as well as the immune exhaustion checkpoint to enhance tumor killing by T cells and NK.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1152463

Entities

People

  • Jaime F. Modiano
  • Shruthi Naik

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Body Weight
  • Cell Line
  • Cells
  • Clinical Trials
  • Data Analysis
  • Data Storage Systems
  • Health
  • Immune System
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Management Personnel
  • Medical Personnel
  • Myeloid Cells
  • Pilot Studies
  • Sarcoma

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech