Acylated Electrospun Biopolymer Membranes for Burn Wound Coverage, Infection Prevention, and Pain Relief
Abstract
We have developed novel biopolymer membranes with advantageous features (physical coverage, infection prevention, pain relief) for immediate care of burn wounds and during prolonged field care. Electro-spun chitosan membranes (ESCM) serve to address burn wound coverage in several ways, including 1) acting as a barrier to microbial contamination, 2) releasing local anesthetics in a controlled manner that reduce pain and modify the inflammatory response, and 3) releasing natural antimicrobial fatty acids that prevent biofilm contamination. In order to assess these ESCM, bulk fabrication of ESCM was performed as well as loading treatments (Bupivicane and/or C2DA) to evaluate elution and antimicrobial properties. Elution results displayed similarities between the single and dual release of C2DA, where controls (sponge and gauze) did not elute therapeutics past 9 hours. Experimental groups (hexanoic, octanoic, and decanoic acylated) eluted therapeutics throughout the study. Antimicrobial results displayed antimicrobial properties of treated membranes against planktonic and biofilm microorganisms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1152648
Entities
People
- Carlos Wells
- Jessica A. Jennings
- Landon Choi
- Rabeta Yeasmin
- Zoe L. Harrison
Organizations
- University of Memphis