Preventing Blood Cancers and Other Malignancies in Military Personnel at Risk Due to Occupational Radiation Exposure

Abstract

We have initiated a project to examine the amino sugar N-acetylglucosamine, via its ability to increase protein OGlcNAcylation, as a means to promote DNA double strand break repair and thereby prevent and mitigate the toxicity of radiation in the bone marrow, toward reducing both the acute and delayed effects, including malignancy. A major challenge has been adapting to limitations related to COVID-19 and then returning to full productivity. After delaying the initiation of research and adjusting our focus, in vitro research is well under way with in vivo studies continuing to lag. Nonetheless, work to date has set the stage for a productive second year of research.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2021
Accession Number
AD1152666

Entities

People

  • Stephen J. Kron

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bone Marrow Cells
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Genetics
  • Medical Personnel
  • Military Personnel
  • Nanoparticles
  • Neoplasms
  • Oxidative Stress
  • Prostate Cancer
  • Stem Cells

Fields of Study

  • Medicine

Readers

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