Targeted Treatment of Traumatic Optic Neuropathy Inspired by Neuroprotective Adaptations of Hibernation
Abstract
The primary objective of this research is to translate adaptive strategies used by hibernators to prevent vision loss associated with head injuries resulting in damage to the optic nerve. Presently there is no consensus on the appropriate treatment for traumatic optic neuropathy. Damage to the optic nerve is irreversible as the nerve fibers dont have the capacity to regenerate on their own, thus preservation of the ganglion cells and their axons under these adverse conditions by mimicking hibernation would represent a novel way to prevent vision loss.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2021
- Accession Number
- AD1152693
Entities
People
- Francisco N. Nicolas
- Kiyoharu J. Miyagishima
- Steven Stasheff
- Wei Li
Organizations
- National Institutes of Health