Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep

Abstract

The present study will investigate the efficacy of a non-pharmacological method of alleviating insomnia by administering both continuous theta burst (cTBS) transcranial magnetic stimulation (TMS) and sham to 20 volunteers (aged 20-40) with self-reported sleep problems. This study will employ a counterbalanced, double-blind crossover study design. It is hypothesized that cTBS administered to a node of the default mode network (DMN) shortly before bed will decrease rumination and facilitate a faster transition from wakefulness to sleep. Anatomical and functional MR imaging data, as well as spectroscopy, will be collected pre- and post-stimulation in order to detect changes in connectivity and chemical composition. Cognitive- and attention-based tasks will be used to characterize changes in cognitive functioning prior to stimulation, immediately after stimulation, and following a night of sleep. We will employ polysomnography and actigraphic sleep monitoring to evaluate sleep quality, latency, and duration.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1152695

Entities

People

  • Natalie S Dailey
  • William S. Killgore
  • Ying Hui Chou

Organizations

  • University of Arizona

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  • Biomedical

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  • Abstracts
  • Biomedical Research
  • Chemical Composition
  • Electronic Mail
  • Insomnia
  • Magnetic Resonance
  • Maryland
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  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Circadian Sleep-Wake Regulation and Chronobiology
  • Computer Networking