Specific-Sized HA35 in Preventing the Transition from Prediabetes to Diabetes
Abstract
More than 7 in 10 veterans who receive VA care are obese or overweight, putting them at high risk for the development of complications of metabolic syndrome, including type 2 diabetes and non-alcoholic fatty liver disease. Obesity and metabolic syndrome are associated with intestinal dysbiosis and impaired intestinal barrier. These changes in the intestine impact the innate immune system to generate a chronic state of low-grade inflammation, termed metaflammation. We have identified a carbohydrate molecule, hyaluronic acid of 35KD, that has a strong potential to interrupt the deleterious inter-organ cross talk between the gut and innate immune system that drives the progression of obesity/pre-diabetes to diabetes. Given the profound protective effects of HA35 in the gut and anti-inflammatory impact on innate immune cells, we hypothesize that HA35 will have a dually-targeted impact acting to protect gut integrity and reduce metaflammation in a murine model of high fat diet-induced obesity, disruptions that are known to contribute to metabolic syndrome/ pre-diabetes to more severe type 2 diabetes and liver injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1152696
Entities
People
- Carol De La Motte