Use of Tranexamic Acid to Reduce Tissue Edema and Prevent Burn Wound Conversion
Abstract
The purpose of the experiments performed during the past year was to elucidate the effect of tranexamic acid (TXA) on burn wound conversion in a rat burn wound conversion model. The comb burn injury model is well validated in the literature for this purpose - particularly at 7 days post injury which represents the gold standard for this experiment. Our studies clearly demonstrated that burn wound conversion was reduced by treatment of rats with intraperitoneal (IP) TXA at this time point. Furthermore, TXA demonstrated efficacy at 24, 48 and 72 hours after comb burn injury. Additionally, we were able to demonstrate that less mitochondrial DNA - an established marker of tissue damage - was reduced at 24 and 48 hours. This finding indicates that TXA has significant cell protecting activity. These findings clearly demonstrate that Tranexamic acid reduces burn wound conversion and has cell protective properties in the rat burn wound conversion model when compared to no treatment. Future experiments will evaluate these properties in the context of severe burn injury. Current findings suggest TXA may be an ideal therapy for burn injured warfighters in the forward deployed setting.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1152698
Entities
People
- Damien Carter
- Igor Prudovsky