Sensitivity Analysis for a Time-Dependent Physiological Model of Superficial Thermal Burns

Abstract

Methods of sensitivity analysis were applied to the reduced time-dependent physiological model describing the local inflammatory response and early fibroblast activity triggered by a first-degree thermal burn. Results of these methods will be used to advance the parameter estimation process as well as identify potential avenues for experiments to support model development. This model will serve as a foundation for building physiologically driven models developed by DTRA to predict casualty distributions after a nuclear detonation event.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1153297

Entities

People

  • Amy Creel
  • Angela Reynolds
  • Rachel Jennings

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Adaptive Immunity
  • Biology
  • Blood
  • Blood Cells
  • Burns
  • Calibration
  • Cardiovascular System
  • Cells
  • Computational Biology
  • Computational Science
  • Diseases And Disorders
  • Equations
  • Leukocytes
  • Lymphocytes
  • Mathematical Models
  • Measurement
  • Medical Personnel
  • Nuclear Weapons
  • Systems Biology
  • T Lymphocytes
  • Thermal Burns
  • Wound Healing
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Physics

Readers

  • Computational Modeling and Simulation
  • Molecular and Cellular Biology
  • Trauma or Military Medicine