Ultrasound-Mediated Nanobiomaterial Delivery for Segmental Bone Fracture Repair
Abstract
Severe bone fractures constitute a complex medical condition. Current treatments have significant complications or side effects. We proposed to develop a new technology, which can generate new bone by activating the patients own stem cells using ultrasound-mediated DNA delivery. We previously showed a proof-of-concept of the technology, named SonoHeal, in alarge animal model. In this project, our goals are to determine the optimal delivery device for the injectable DNA and the standard operating procedures for handling and mixing the final product at the clinical site. Furthermore, we aimed to demonstrate the reproducibility and the accuracy of delivering the DNA to the target site. Lastly, we would conduct a toxicology study using the proposed therapy to treat critical-size bone fractures. In the first year of the project, we obtained the necessary approvals to conduct the studies, generated a manual to use the technology in the clinical settings and conducted a study in minipigs to determine the reproducibility and accuracy of DNA delivery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1153319
Entities
People
- Dan Ganzit
Organizations
- Cedars-Sinai Medical Center