Effects of Hypobaria on Systemic Immune Function Following Brain Trauma
Abstract
In these preclinical studies we examined systemic and central immune function following experimental traumatic brain injury (TBI; controlled cortical impact) plus secondary hypobaria exposure in adult male C57Bl/6J mice. The experimental animals were also subjected to a battery of neurobehavioral tests to probe posttraumatic motor and cognitive deficits. The studies were designed to test the hypothesis that exposure to hypobaria after experimental TBI will result in an amplification of neuroinflammation and increased neurological dysfunctions compared to animals subjected to TBI alone. Our data have shown only minor evidence of hypobaria-induced increases in inflammation responses after TBI and no evidence of worsening of neurological deficits.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 23, 2021
- Accession Number
- AD1153921
Entities
People
- Alan Faden
- Bogdan Stoica
- Catriona Miller
- David Loane
Organizations
- University of Maryland