Comparative Serum Pharmacokinetics of Per- and Polyfluoroalkyl Substances (PFAS) in White-Footed Mice (Peromyscus leucopus)
Abstract
Per- and polyfluoroalkyl substances (PFAS) are compounds manufactured for use in paints, cleaning agents, fire suppressants, non-stick cookware and food containers, and water-resistant products. Concerns about some perfluorooctyl-based PFAS, such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), stem from their ubiquitous presence in the environment, widespread reports of general toxicity in laboratory animals, and the resistance of these compounds to degradation. In the present study, five perfluoroalkyl substances and one polyfluoroalkyl substance were administered to whitefooted mice (Peromyscus leucopus) to elucidate the accumulation of each chemical over 28 days of exposure. In general, similar serum levels at two time points depended on (i) the type of PFAS (i.e., perfluoroalkyl sulfonic acids (PFSAs), perfluoroalkyl carboxylic acids (PFCAs), or polyfluorinated), (ii) continuous vs. bolus dosing, (iii) dose, and (iv) sometimes sex.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 24, 2021
- Accession Number
- AD1154445
Entities
People
- Allison M. Narizzano
- Meredith E Bohannon
- Michael J. Jr Quinn
Organizations
- United States Army Public Health Command