Strategies to Counteract Resistance Mechanisms in CAR+ T-Cell-Based Immunotherapy for Triple-Negative Breast Cancer

Abstract

This is the final report of our awarded proposal entitled "Strategies to Counteract Resistance Mechanisms in CAR T-Cell Based Immunotherapy for Triple-Negative Breast Cancer". The goal of this proposal is to test the in vitro and in vivo anti-tumor activity of the CSPG4-specific CAR T cell combinatorial immunotherapeutic strategy we have developed for the treatment of TNBC. Given the limited in vivo effectiveness of our strategy, we have tested a plethora of strategies aiming to enhance the ant-tumor activity of CSPG4 CAR T cells via distinct approaches and mechanisms.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2020
Accession Number
AD1154909

Entities

People

  • Barbara Savoldo
  • Gianpietro Dotti

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Blood
  • Body Fluids
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Culture Techniques
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Molecules
  • Statistical Analysis
  • T Lymphocytes

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech