COLON-MD: Colon Cancer Longitudinal Study of the Microbial and Dietary Factors That Influence Response to Treatment

Abstract

Colorectal cancer (CRC) stages II/III are optimally treated with chemotherapy (e.g. FOLFOX) and surgery. However, up to 50 percent of CRC patients experience chemotherapy-induced diarrhea (CID), which can lead dose reduction and be life-threatening. There are no biomarkers for predicting risk or severity of CID. The purpose of this study is to understand the dietary and microbial factors that are associated with incidence and severity of CID and develop a predictive biomarker. I aim to study patient-derived biospecimens and dietary recall to identify microbial and dietary changes that are predictive of incidence and severity of CID to inform future studies of CRC treatment response.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1154962

Entities

People

  • Leigh Greathouse
  • Lucas Wong

Organizations

  • Baylor University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Bacterial Infections
  • Bacteroidaceae
  • Biodegradation
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Colon Cancer
  • Epithelial Cells
  • Gut Microbiome
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Microbiology
  • Microbiomes
  • Therapy

Fields of Study

  • Medicine

Readers

  • Civilian Systems Systems Program Capability Development and Upgrade Support Activity Expense and Pay Management.
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech