Defining the Role for Descending Pain Modulation and Reward- Aversion Processes Towards the Development of Chronic Pain in Endometriosis
Abstract
Endometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women, is the leading cause of chronic pelvic pain (CPP), and is often unresponsive to existing treatments. Unfortunately, womens reproductive health has lacked investigation in biomedical research; however, given that approximately 1 in 10 women worldwide have endometriosis this research is warranted. Further research on the biopsychosocial mechanisms contributing to endometriosis-associated pain is necessary to better inform treatment and prevention and is the goal of the current proposal. In respect to the COVID-19 pandemic, recruitment and data collection was delayed. However, we currently have recruited and tested 10 participants, with 11 participants on the schedule, and 11 more who have expressed interest and who are in the process of being scheduled. The research team has also published several papers related to the project and have three papers in preparation (two reviews; preliminary resting state data) during this reporting period and have attended various webinars and training related to the project. Additionally, Dr. Borsook(Partnering PI) retired from BCH and transitioned to the position of consultant for the current project. Dr. Holmes assumed Dr. Borsooks role on February 10th, 2021. Lastly, the imaging center at BCH has moved locations. The MRI aims of the current project will now take place at 2 Brookline Place, Boston, MA 02215. In the report last year, the research team had proposed alternatives to counteract the setbacks that the project faced due to COVID-19, which included: (1) Partnering with other Harvard Medical School (HMS) affiliated hospitals to aid in recruitment. The research team has increased the number of partnering gynecological surgeons at HMS, thus increasing our recruitment pool for people with endometriosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2021
- Accession Number
- AD1154968
Entities
People
- Christine B Sieberg
- Scott Holmes
Organizations
- University of Michigan