Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease

Abstract

The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using "designer" dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms. During this reporting period 17 new human subjects were successfully recruited at this performance site.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1155392

Entities

People

  • Ali Keshavarzian
  • Leonard Verhagen

Organizations

  • Rush University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Gut Microbiome
  • Instructions
  • Internet
  • Law
  • Management Personnel
  • Maryland
  • Medical Personnel
  • Metabolites
  • Microbiomes
  • Motor Disorders
  • Neuroglia
  • Organizational Structure
  • Parkinson'S Disease
  • Patent Applications
  • Pathogenesis
  • Professional Development
  • Targeting
  • Technology Transfer

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Microbial Pathology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology