Using Affinity-Based Proteomics to Identify Diagnostic and Plasma Biomarkers for Endometriosis
Abstract
During the past year, we evaluated the association between 1,305 proteins in blood samples from 142 confirmed endometriosis cases and 74 controls participating in the Womens Health Study: From Adolescence to Adulthood (A2A) and identified 63 proteins significantly associated with endometriosis with an absolute fold change of greater than 1.2. Furthermore, we identified biological pathways associated with endometriosis, including cell migration and angiogenesis that were upregulated in endometriosis compared to controls (p less than 6.0x10(exp -9)). Furthermore, we observed that few proteins overlapped across lesion colors, suggesting different etiologic pathways. These findings were presented in an oral presentation at the World Congress of Endometriosis in March 2021. Among the cases we also evaluated proteins and pathways associated with persistent pain. These results were accepted for an oral presentation at the annual ASRM meeting to be held in October 2021. Finally, proteomics data was recently received on NHSII samples and quality control analyses are currently under way.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1155398
Entities
People
- Kathryn L. Terry
Organizations
- Brigham and Women's Hospital