Vitamin D Deficiency Leads to Increased Intraprostatic Hormones in African American Men

Abstract

Our most significant finding for Y2 of this project is the profound defect in prostate differentiation observed in the organoids lacking Megalin, which supports its role in hormone import. We have also focused in HSD17B7 as a key gene differentially expressed by African Ancestry. HSD17B7 is a key enzyme for estrogen metabolism and we found that it is higher in AA prostate stroma on a TMA. Further, HSD17B7 expression is increased by estrogen and androgen in patient-derived stromal cells, validating the microarray data.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2021
Accession Number
AD1155403

Entities

People

  • Larisa Nonn

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Acquisition
  • African Americans
  • Androgens
  • Biomedical Research
  • Data Analysis
  • Gene Expression
  • Hormones
  • Illinois
  • Medical Personnel
  • Nutrition Disorders
  • Prostate Cancer
  • Sex Hormones
  • Statistical Analysis
  • Students
  • Tissues
  • Universities
  • Vitamin D

Readers

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