T Cells and Rejection in Vascularized Composite Allotransplants

Abstract

Immune rejection is a major barrier to wider implementation of vascular composite allografts (VCAs) that hold great promise for restoring function in American service members, who have suffered devastating traumatic injuries. Despite systemic immunosuppression, T cell mediated rejection (TCMR) occurs much more frequently in VCA than in solid organ transplants, likely due to the significant number of donor T cells that survive in the allografts. This study will use banked tissues from VCA patients to comprehensively analyze the contributions of donor versus recipient T cells in VCA rejection. Another question that will be addressed is whether sentinel flaps, transplanted concomitantly with the allograft from the same donor to a distant anatomical site, or circulating levels of clonally expanded T cells, are useful as reliable markers for VCA rejection. IRB and HRPO approval for this project has been obtained.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2022
Accession Number
AD1155723

Entities

People

  • Bohdan Pomahač
  • Rachael Clark

Organizations

  • Brigham and Women's Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Cells
  • Composite Materials
  • Health Services
  • Hospitals
  • Lymphocytes
  • Maryland
  • Medical Personnel
  • Optimization
  • Professional Development
  • Rejection
  • Rna Sequence Analysis
  • Surgery
  • Technology Transfer
  • Transplants

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Oncology

Technology Areas

  • Biotechnology