An Investigation of Serum Levels of Per- and Polyfluoroalkyl Substances and Testicular Cancer Risk Within the Department of Defense Serum Repository
Abstract
Per- and polyfluoroalkyl substances (PFAS) are substances used until recently in the manufacture of aqueous film forming foams (AFFF) for firefighting, non-stick cookware, and other products. Military sites with a history of using AFFFs have been identified as a major source of PFAS water contamination for several communities. However, the level of exposure to PFAS experienced by military personnel is unclear. Limited evidence suggests that perfluorooctanoic acid (PFOA), one of the most produced and studied PFAS, is associated with increased risk of testicular cancer. To clarify this research question, we plan to conduct a case-control study of serum PFAS levels and testicular cancer risk nested within the Department of Defense Serum Repository (DoDSR). We will measure PFAS levels in the earliest and latest available banked serum samples stored in DoDSR from 500 Air Force servicemen who later developed testicular cancer, identified through the DoD Automated Central Tumor Registry, and 500 Air Force cancer-free controls. Serum levels of PFOA and nine other PFAS analytes will be measured using automated solid-phase extraction coupled to reversed-phase high-performance liquid chromatography-tandem mass spectrometry at the Centers for Disease Control and Prevention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1155743
Entities
People
- Jennifer Rusiecki
- Mark P. Purdue
Organizations
- Geneva Foundation