Targeting the Endotheliopathy of Trauma in Hemorrhagic Shock and Traumatic Brain Injury with Freeze-Dried Platelets

Abstract

The goal of this project is to test the therapeutic potential of freeze dried platelets-FDPlts (Thrombosomes)- in disease conditions characterized by 1) inflammation, 2) vascular instability and 3) coagulation disturbances, which are all components of the endotheliopathy of trauma (EOT) (refs). Aside from their hemostatic properties, this proposal aims to also determine the mechanisms of action of the freeze dried platelets (FDPlts (Thrombosomes)) on the EOT in traumatic brain injury (TBI) and shock induced acute lung injury (ALI); all conditions with few if any effective treatment options. We hypothesize that FDPlts (Thrombosomes) will have potent hemostatic properties comparable to fresh platelets and that they will attenuate and mitigate the endotheliopathy of trauma (EOT) in TBI and HS induced ALI. We hypothesize that FDPlts (Thrombosomes) can be used as a stand-alone early therapy to mitigate outcomes in trauma.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1155745

Entities

People

  • Alpa Mahuvakar
  • Shibani Pati

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood-Brain Barrier
  • Brain Injuries
  • Cells
  • Computer Programs
  • Computers
  • Data Analysis
  • Department Of Defense
  • Endothelial Cells
  • Freeze Drying
  • Gel Electrophoresis
  • Hemorrhagic Shock
  • Intercellular Junctions
  • Mass Spectrometry
  • Spectrometry
  • Tissues
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Trauma Surgery or Emergency Medicine.