Multi-Omics and Mitochondrial Dysfunction in Acute Lung Injury

Abstract

This proposal addresses the FY18 PRMRP Topic Area of Acute Lung Injury, utilizing novel approaches (metabolomics, lipidomics, and mass spec imaging) to identify the causes of sepsis-induced acute lung injury (ALI) and biomarkers which differentiate patients at risk of developing ALI from those not at risk. This project also proposes the development and testing of a potential new drug, BTP2, to reduce the incidence and/or severity of ALI.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1155748

Entities

People

  • Madesh Muniswamy

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Carboxylic Acids
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Cytokines
  • Endothelial Cells
  • Infection
  • Inflammation
  • Intracellular Membranes
  • Medical Personnel
  • Molecules
  • Proteins
  • Rate Of Consumption
  • Sepsis
  • Wound Infections
  • Wounds And Injuries

Readers

  • Molecular and Cellular Biology
  • Naval Engineering and Maritime Security
  • Trauma or Military Medicine