Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Abstract

We are interested in determining whether ambient air pollutants impact the development of Parkinson's disease by increasing -synuclein (-syn) pathology via inflammation. After completing Specific Aim 2, wherein we found no differences between experimental groups in spread of -syn, we discovered our collected nPM did not produce the expected neuroinflammatory changes. We are now poised to begin Specific Aim 3 mouse experiments to define the effects of LPS-induced olfactory inflammation on spread of -syn by histological (VARI) and biochemical (USC) analyses (under continued travel restrictions).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1156087

Entities

People

  • Patrik Brundin

Organizations

  • Van Andel Institute

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Air Pollutants
  • Biomedical Research
  • Department Of Defense
  • Diseases And Disorders
  • Dysfunction
  • Immune System
  • Inflammation
  • Lead Compounds
  • Lymphocytes
  • Medical Personnel
  • Nervous System
  • Neurodegeneration
  • Parkinson'S Disease
  • Personnel Management
  • Sars

Fields of Study

  • Biology

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design