Racial Disparities in Active Surveillance Adherence and Quality of Life in a Population-Based Prospective Cohort of Men with Low-Risk Prostate Cancer
Abstract
Active surveillance (AS) is recommended for men with low-risk localized prostate cancer (LPC) to reduce overtreatment and to maintain the patients quality of life. However, whether African American (AA) men can safely undergo AS is controversial due to concerns of more aggressive disease and lack of empirical data on the safety and effectiveness of AS in this population. This project extends follow-up of a population-based cohort study of 1800 (~21 percent AA) patients diagnosed with low-risk LPC from 2014 to 2017 prospectively recruited through two NCI-sponsored SEER registries. All cases who initially chose AS or watchful waiting (WW), and a subset of cases who received surgery or radiation at baseline were selected for a follow-up survey at 18 months after baseline and again at 5 years after diagnosis. Aim 1: Identify racial differences in men's adherence to AS protocol, switch rates and time to curative treatment over the course of 5 years from diagnosis. Aim 2: Compare quality of life (QOL) measures between AS group and treatment group over the course of 5 years, overall and by race. Aim 3: Evaluate whether reasons for switching from AS to curative treatment differ by race So far, we have received a total of 617 (511 White, 106 Black) 5-year follow-up surveys, ~70 percent of the recruitment goal (n=880). Among them, a total of 67 (56 White, 16 Black) patients who were on AS at 2 years have switched to definitive treatment at 5 years after diagnosis. The recruitment is ongoing at both study sites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1156245
Entities
People
- Jinping Xu
Organizations
- Wayne State University