Intravesical Lactobacillus to Reduce Urinary Symptoms after Spinal Cord Injury
Abstract
This proposal specifically focuses on the population of people with SCI and neurogenic bladder who manage their bladders with intermittent catheterization (IC). The objectives of this study are to: 1) define clinically meaningful change (i.e., differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, and the urinary tracts microbial ecosystem; 2) determine the optimal intravesical LactobacillusGG. (LGG.) dose to reduce urinary symptoms for use in a future clinical trial; and 3) advance diagnosis, self-management, and clinical research around urinary symptoms in SCI by developing a method for doing research that leverages computational methods, but focuses on integrating the patients report of symptoms with gold standard (urinalysis and urine culture) and novel (urine NGAL and sequencing) clinical data to reliably detect changes from normal that are clinically meaningful and interpretable-both within and across people. Applicability: The short-term applicability of this work directly and immediately includes advancing: 1) self-management of symptoms with intravesical LGG.; and 2) diagnostics through differentiation of asymptomatic bacteriuria from urinary tract infection through use of uNGAL. The long-term applicability of this work includes advancing: 3) prevention of UTI with LGG.; and 4) reduction in over-prescription of antibiotics and resistant microbes. Impact on Persons with SCI: This work specifically targets people with SCI who use intermittent catheters (due to neurogenic bladder). These individuals will potentially be helped by having an easily accessible method to reduce, through self-management, frequent and burdensome urinary symptoms, reducing the occurrence of UTI and ultimately, antimicrobial resistance due to overuse of antimicrobials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2021
- Accession Number
- AD1156251
Entities
People
- Inger Ljungberg
- Suzanne Groah
Organizations
- National Rehabilitation Hospital