Developing an Ideal First Use Agent to Prevent Sepsis in Trauma Wounds During Care Under Fire
Abstract
The primary purpose of the work performed was to test and advance a wound and drug delivery system under conditions that simulated thematerials ability to (1) transform and form a dressing that will act as a primary material to provide benefits of moist wound healing, (2) contain a clotting agent and demonstrate that the dressing combined with clotting agents performs the same or better than current standard of care, and (3) provide controlled antimicrobial release profiles over periods of up to 72 hours. Over 60 different prototypes of wound dressings weremanufactured by combining the base materials with a number of antimicrobial and clotting agents at varying dosages. Each sample was tested for its physical properties and ability to maintain a moist environment. Antimicrobial effectiveness of the antimicrobial combinations was tested in-vitro with gram positive and gram negative bacteria. The viability of a controlled release of embedded drugs over an extended time period was also tested. Our research indicated that a dressing solution with various active therapeutic agents can be successfully formulated to provide a moist wound healing solution that can deliver highly effective clotting or antimicrobial agents beyond a 72-hour period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 2021
- Accession Number
- AD1156513
Entities
People
- Howard Callahan
- Vaidehi Shah