Preventing Ototoxic Synergy of Prior Noise Trauma during Aminoglycoside Therapy
Abstract
Upon the conclusion of the project, we have successfully identified two molecular targets among a handful candidates that contribute to an escalated inner ear ototoxicity. One is the Duffy antigen receptor for chemokines (Darc), and the other is the transient receptor potential vanilloid 1 (TrpV1). Both receptors actively mediate the process of cochlear inflammation, a lesser-previously researched condition resulting from exposure to moderate and intense noise stimulation, as well as other inner ear insults. In the present project, we used electrophysiology, immunohistochemistry, and cochlear perfusion techniques to conduct proposed experiments. The effect of inflammation on drug- or noise-induced ototoxicity was investigated in depth, such as using the applications of LPS and aminoglycosides. Acquired data were analyzed thoroughly, resulting in numerous conference abstracts and peer-reviewed publications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2021
- Accession Number
- AD1156530
Entities
People
- Hongzhe Li