Optimizing Surgical Debridement Following High-Energy, Open Trauma With Dynamic, Contrast-Enhanced Fluorescence Imaging

Abstract

The proposed study will enroll 180 patients with open fractures to determine whether bone perfusion parameters, as measured byindocyanine green (ICG)-based Dynamic Contrast Enhanced Fluorescence Imaging (DCE-FI), is a predictor of unplanned all-causereoperation as defined by the Centers for Disease Control and Preventions (CDC) National Healthcare Safety Network reporting criteria. Wewill also modify and optimize the existing DCE-FI system for bone perfusion imaging in austere environments and/or forward operating units.This study represents the next important step towards optimizing surgical management of high-energy traumatic injuries, particularly inmedical units supporting soldiers in battle. This will transform the current paradigm by providing military trauma surgeons with accessibletools that can be used by surgeons at any level of experience to objectively inform surgical debridement. In turn, this technique will directlyimprove patient outcomes after traumatic injury by reducing infection and complications requiring unplanned reoperation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1156647

Entities

People

  • Ida L. Gitajn
  • Jonathan T. Elliott
  • Melanie L. Christian
  • Shudong Jiang

Organizations

  • Dartmouth–Hitchcock Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Flow
  • Bone Fractures
  • California
  • Data Analysis
  • Data Processing
  • Debridement
  • Department Of Defense
  • Engineering
  • Environment
  • Health Services
  • High Energy
  • Image Processing
  • Light Sources
  • Medical Personnel
  • Patent Applications
  • White Light

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine