Genetic and Environmental Influences on the Pathogenesis of Parkinson's Disease: Young Adult Brain and Behavioral Risk Indicators

Abstract

This study addresses questions about the causes and progression of Parkinsons disease (PD) over the life course, specifically with respect to the role of a toxic chemical exposure, chlorpyrifos (CPF), an organophosphate pesticide. To understand how early exposure to CPF affects the nervous system, genetic susceptibility to CPF, and the long term consequences of exposure, we are studying 200 young adults in an urban community cohort, now reaching 19-20 years of age, many of whom were routinely exposed to residential pesticides, as measured by a biomarker of CPF in cord blood. We are conducting neurological assessments of stiffness and gait, cardiac measures, sleep questions, measures of tremor, olfactory status, and other neuropsychological measures. We have access to previously-collected genetic information. The assessment requires 45-50 minutes; participants are paid $100 and cost of transportation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1156680

Entities

People

  • Virginia Rauh

Organizations

  • Columbia University

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Biomedical Research
  • Computers
  • Covid-19
  • Data Analysis
  • Diseases And Disorders
  • Genes
  • Genetics
  • Health Services
  • Heart Rate
  • Institutional Review Board
  • Medical Personnel
  • Mental Processes
  • Movement Disorders
  • Parasomnias
  • Parkinson'S Disease
  • Statistical Analysis
  • Universities

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.

Technology Areas

  • Biotechnology