Multi-Omics and Mitochondrial Dysfunction in Acute Lung Injury

Abstract

Traumatic injury is a leading cause of respiratory failure, where 2-4 percent of persons with trauma develop acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Approximately one-third of the patients progress to ALI/ARDS, and an estimated mortality rate of 40 percent is seen in trauma-associated ALI/ARDS. Furthermore, in ARDS, Acute Kidney Injury (AKI) is the most frequent organ failure affecting almost 50 percent of the patients, increasing the mortality rate. Therefore, understanding the molecular differences between the survivor and non-survivors of ALI and developing biomarkers to predict ALI progression are urgently needed.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1156688

Entities

People

  • Andriy I. Batchinsky
  • Annapurna Pamreddy
  • Daniel Montemayor
  • Hongping Ye
  • Jae H. Choi
  • Jingli Gao
  • John J Kim
  • Kumar Sharma
  • Pragya Singh
  • Viktor Drel

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Amino Acids
  • Biomedical Research
  • Blood
  • Cells
  • Endothelial Cells
  • Hemorrhagic Shock
  • Inflammation
  • Lung Diseases
  • Maryland
  • Mass Spectrometry
  • Metabolism
  • Metabolomics
  • Organic Acids
  • Risk Factors
  • United States
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Mathematics or Statistics
  • Neurotrauma and Rehabilitation Medicine.