Therapeutic Small Molecule and Timed Limb Stabilization Strategies to Prevent Complications of Extremity Trauma and Enhance Return to Duty
Abstract
The central goal of this project is to change the Standard Practice Guidelines for extremity trauma in a PFC scenario to prevent the 2 main barriers to return to duty: IRI and HO. Specifically, we will target mechanotransduction through a readily deployable therapeutic and an easily followed mobilization protocol. Specifically, we will evaluate the efficacy of therapeutic strategies that target mechanotransduction through focal adhesion kinase (FAK) and YAP/TAZ signaling as well as a clinically relevant post-injury immobilization protocol to prophylax against IRI organ injury and HO. Our overall goal is to generate a paradigm shift in our approach to patients with severe extremity trauma and tourniquet use to include an easily deployable orally bioavailable therapeutic and a synergistic early limb immobilization strategy to mitigate the systemic effects if IRI and to prevent HO. We hypothesize that mechanotransductive signaling is critical for IRI and HO and that pharmacologic or occupational therapy based inhibition of the FAK pathway will prevent trauma-induced HO and limit IRI organ dysfunction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1156694
Entities
People
- Benjamin Lévi
Organizations
- University of Texas at Austin