Intratumoral Heterogeneity of Aggressive Molecular Biomarkers in Lethal Primary Prostate Cancer
Abstract
Over the past fifteen years, our understanding of the biology of prostate cancer has increased dramatically, and a number of specific genetic changes (i.e., biomarkers) have been identified that help us predict which patients with die from prostate cancer. At the same time, however, other research has shown that these genetic changes can vary significantly within a single tumor - a concept known as intratumoral heterogeneity and the possibility of intratumoral biomarker heterogeneity represents a significant challenge to our ability to predict which patients will die from prostate cancer. In this study, we hypothesize that tumors in patients who eventually die from prostate cancer show increased intratumoral biomarker heterogeneity that is associated with other types of genetic changes. To examine this hypothesis, we are in the process of assessing how frequently specific biomarkers show intratumoral heterogeneity in these tumors and identifying the types of corresponding genetic changes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1156703
Entities
People
- Aaron M. Udager
Organizations
- Board of Regents of the University of Michigan