Genome-Wide Association Study in Acquired Aplastic Anemia

Abstract

Aplastic Anemia (AA) is a previously universally fatal disease characterized by a hypocellular bone marrow and pancytopenia. AA incidence is skewed across the globe, being 2-3 fold higher in Asia than in Europe. In a variety of studies, chemical exposures and infections in different geographic areas have been described as risk factors for AA, but inconsistently, based on small sample sizes, and at prevalence too low to account for large geographic differences. Genome wide association study GWAS is a powerful research method that compiles genetic variants from many individuals to investigate the association of common genetic markers with a disease phenotype. It has led to the discovery of important new genes and associations in a number of medical conditions.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1156796

Entities

People

  • Neal Young

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Agreements
  • Biomedical Research
  • Blood Transfusions
  • Genetics
  • Geographic Regions
  • Governments
  • Health Services
  • Hematologic Diseases
  • Humanities
  • Local Governments
  • Maryland
  • Medical Personnel
  • Professional Development
  • Technology Transfer
  • Training
  • United States
  • Universities

Readers

  • Immunology and Pathology
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology