Supersaturated Oxygen Emulsion as a Novel Topical Treatment for Ocular Chemical Injury
Abstract
The purpose of the project is to develop a novel supersaturated oxygen emulsion (SSOE) for ophthalmic use to treat acute chemical injury to the eye. The major goals are: 1)Manufacture, optimize, and characterize SSOE for ocular application; 2) Determine the safety and efficacy of immediate SSOE application in mitigating acute ocular burn in vivo; and 3)Determine the efficacy of delayed SSOE application in preventing tissue damage and promoting tissue repair after ocular burn in vivo. In the first year of the project, we have accomplished the following tasks: 1) SSOE containing three concentrations of the active ingredient perfluorodecalin (PFD, 15, 25, and 35%) were successfully manufactured for ophthalmic use; 2) All three formulations of SSOE release oxygen immediately and potently with 35% SSOE having the longest release duration; 3) SSOE was found to be safe to culture human corneal cells (epithelial, stromal, and endothelial cells) in vitro; and 4)SSOE, either applied one-time only or daily for 2 weeks, was found to be safe to mouse eyes in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1156811
Entities
People
- Jia Yin
Organizations
- Schepens Eye Research Institute