Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease

Abstract

The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1158148

Entities

People

  • Viviana Gradinaru

Organizations

  • California Institute of Technology

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • California
  • Department Of Defense
  • Diseases And Disorders
  • Gut Microbiome
  • Maryland
  • Metabolites
  • Microbiology
  • Microbiomes
  • Microorganisms
  • Parkinson'S Disease
  • Patent Applications
  • Pathogenesis
  • Professional Development
  • Students
  • Technology Transfer
  • Trainees

Readers

  • Microbial Pathology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology