Multimodal Intervention Trial for Cognitive Deficits in Neurofibromatosis Type 1: Efficacy of Computerized Cognitive Training and Stimulant Medication

Abstract

Children with NF1 demonstrate working memory difficulties which impacts cognitive and academic functioning. One hundred and three children with NF1, age 8-16 years (M = 11.37 years, SD = 2.21) at four participating sites (50.5 percent Male, 78.6 percent Not Hispanic/Latino, 68.0 percent White, 14.6 percent on stimulant medication), were screened using a battery of neurocognitive tests and parent-completed questionnaires. The intervention phase included 82 children (who were stratified by stimulant medication use and randomized equally between two interventions: CogmedRM (n =41), or the active control, MobyMax, an online reading program (n = 41). Children who completed CogmedRM did not outperform children who completed MobyMax but demonstrated improvement on digit span backward and spatial span forward. This computerized, home-based working memory training program was acceptable, feasible, and enjoyable for children and adolescents with NF1.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2021
Accession Number
AD1158214

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  • Kaitlyn Tiplady
  • Kristina Hardy

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  • Biomedical

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  • Psychology

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