A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry
Abstract
Objective: Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West Africanancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationshipswith a view to informing prevention and therapeutic strategies. Impact: Our study will be the first to explore the relationship between systemic/chronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1158225
Entities
People
- Stefan Ambs
Organizations
- Geneva Foundation