Heparin-Free Minimal Invasive Extracorporeal Life Support Treatment of Acute Lung Injury
Abstract
The purpose of this project is to develop a blood-compatible surface coating for extracorporeal life support (ECLS) devices to prevent thrombus formation during circulation without use of heparin. The coating catalyzes nitric oxide (NO) release in blood, preventing platelet activation. This would enable ECLS in trauma and combat casualties with coagulopathic complications contraindicating the use of heparin. In this first year of the period of performance we have applied the coating to ECLS tubing and catheters and have demonstrated NO-release and reduction in bacterial adhesion. When compared to clinically available ECLS circuits with anticoagulant coatings (immobilized heparin and albumin) performance of the NO-releasing coating was similar and enabled circulation of donor blood for 6 hours. To date the coating cannot be applied to ECLS membranes due to surface characteristics of the polymer, as discovered by our collaborators at Colorado State. To solve this problem, we propose use of NO gas directly delivered into membrane sweep gas. This alternative strategy is based on some preliminary data from the literature, has been tested in pilot studies by our group and was found to be feasible. Further testing will be performed in vivo in healthy and injured swine carried out to a prolonged field care timeline as envisioned in this grant (72hrs).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1158806
Entities
People
- Andriy I. Batchinsky