Proteomic Discovery of Potential Biomarkers in Zika Virus Infected Monkeys
Abstract
Zika virus (ZIKV) was first discovered in Macaca mulatta (rhesus monkeys) in 1947 and was found in humans in 1952. This virus can be transmitted via the bite of an infected mosquito, through sexual transmission, or from mother to child. Although most infected individuals are asymptomatic, some clinical symptoms of the virus include fever, joint pain, and rash, as well as microcephaly in infants of infected mothers. The World Health Organization (Geneva, Switzerland) announced a public health emergency in 2016 in response to outbreaks of ZIKV and its association with microcephaly; however, there has been limited progress in discerning how this virus impacts the host. Here, we report on the use of a proteomic pipeline to analyze plasma samples of ZIKV-infected macaques to identify biomarkers for the virus. The discovery of ZIKV biomarkers will assist in defining virus behavior during infection and will illustrate how the host is affected.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2022
- Accession Number
- AD1159061
Entities
People
- Bao Q. Tran
- Daniel Carmany
- Elizabeth S Dhummakupt
- Gabrielle Rizzo
- Phillip M Mach
- Trevor Glaros
Organizations
- United States Army Combat Capabilities Development Command