Herpesviruses and Immune Dysregulation in Pulmonary Fibrosis

Abstract

The objective of these studies is to determine the role of human herpesviruses and antiherpes virus immunity in the development of idiopathic pulmonary fibrosis. The first aim of the study is to collect peripheral blood and broncholalveolar lavage fluid from patients with IPF or other ILDs undergoing clinical bronchoscopy, quantify viral load and perform immunophenotyping of circulating and BAL immune cells. The second aim is to use a model of genetic risk for IPF to investigate the mechanisms of herpesvirus-driven experimental fibrosis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1159618

Entities

People

  • Timothy S. Blackwell

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biomedical Research
  • Cells
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Epithelial Cells
  • Health Services
  • Lung Diseases
  • Lymphocytes
  • Medical Personnel
  • T Lymphocytes
  • Viral Load

Fields of Study

  • Biology

Readers

  • Immunology and Pathology

Technology Areas

  • Biotechnology