Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression

Abstract

The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis (OA) and pain associated with OA using mouse genetic models. Two major aims are proposed.1) assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2) assessment of OA-associated pain in Piezo2 haplo-insufficient mice.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1159625

Entities

People

  • Tatsuya Kobayashi

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Ablation
  • Animals
  • Arthritis
  • Biomedical Research
  • Bone And Bones
  • Breeding
  • Cartilage
  • Connective Tissue Cells
  • Disease Attributes
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Hospitals
  • Laboratory Animals
  • Management Personnel
  • Maryland
  • Medical Personnel
  • Organizational Structure
  • Pain
  • Professional Development
  • Students
  • Targeting

Readers

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  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology