The Role of Mitochondria in ADT-Induced Sarcopenia in Prostate Cancer Patients

Abstract

Prostate cancer (PCa) is the most common cancer among men. Androgen deprivation therapy (ADT)is the standard treatment for advanced and metastatic PCa and nearly 400,000 men remain onandrogen deprivation therapy (ADT) for advanced PCa in the U.S. Unfortunately, ADT alsoinduces a decrease in muscle mass and function, known as sarcopenia, a condition that leadsto decreased endurance, increased fatigue, falls, poor health-related quality of life (HRQOL) and increased mortality. The mechanisms underlying the development of ADT-inducedsarcopenia are incompletely understood and remain a significant barrier to the development oftherapies for this condition. Mitochondria play an essential role in generating the adenosinetriphosphate (ATP) needed for muscle contraction and abnormalities in mitochondria functionhave been reported in animal models of sarcopenia. The extent to which mitochondrialdysfunction mediates ADT-induced sarcopenia and muscle dysfunction is not known.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1160971

Entities

People

  • José M. Garcia

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biomedical Research
  • Body Composition
  • Cancer
  • Clinical Trials
  • Department Of Defense
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Health Care
  • Health Services
  • Lung Diseases
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Quality Of Life
  • Training
  • United States

Fields of Study

  • Medicine

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