Mechanism-Based Prevention of Noise-Induced Tinnitus: Protection and Repair of Peripheral Auditory Neuropathy
Abstract
Studies test a potential treatment for noise-induced tinnitus in the rat model. We hypothesize that noise-induced loss of synaptic connection between Inner Hair Cells (IHC) and the auditory nerve (AN) contributes to the induction of tinnitus and rapidly repairing this loss will therefore decrease the incidence of tinnitus. Treatment with the neurotrophic factor NT-3 was previously shown by our consultant Dr. Corfas to induce significant IHC-AN synapse reconnection after a different type of noise in his mouse model (Suzuki et al., 2016). During the first year of studies we have found that we can duplicate these results using a more military relevant small arms fire (SAF)-like noise in the rat model, showing a large and significant re-connection (described later in Section 3 of the Results Section). NT3 in poloxamer was applied to the round window with the trans-tympanic approach that has been successfully applied in people for other treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1162378
Entities
People
- Avril G. Holt
Organizations
- Wayne State University