The Impact of the Dura Mater on Prostate Spine Metastases

Abstract

Purpose: Understanding the influence of the dura and its secreted cytokines is the goal of the proposed project. Scope: We intend to examine the effects of dura and its released cytokines on the invasion and growth of prostate cancer cells in-vitro and in-vivo and explore a possible mechanism for these effects. Major findings: Over this period, we have found that when dura is exposed to tumor that it changes the dura and leads to increase in certain cytokines these do not significantly effect tumor growth, migration or invasion. It leads to increase in cytokine release of il-6 and other inflammatory cytokines.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1163382

Entities

People

  • Nicholas J. Szerlip

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Central Nervous System
  • Culture Media
  • Culture Techniques
  • Cytokines
  • Dura Mater
  • Inhibitors
  • Maryland
  • Medical Personnel
  • Michigan
  • Neoplasms
  • Nervous System
  • Prostate
  • Prostate Cancer
  • Spine
  • Universities

Fields of Study

  • Medicine
  • Physics

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Molecular Biology and Genetics