Extracellular Vesicles as Potential Drivers of Myelin Health and Myelin Repair in Pregnant MS Patients

Abstract

This research study explores whether Extracellular Vesicles (EVs) that are produced during pregnancy may have beneficial roles in Multiple Sclerosis, in particular, to myelin health and/or repair capacity. We have purified and characterized EVs from both pregnant and control mice, have performed pilot studies to determine the effect of pregnancy EVs on oligodendrocyte progenitor cell proliferation, differentiation, and myelin gene expression, and have begun our efforts to sequence miRNA cargos contained within pregnancy EVs.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2021
Accession Number
AD1163394

Entities

People

  • Holly Colognato

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Alzheimer Disease
  • Biomedical Research
  • Brain
  • Cells
  • Controlled Environment
  • Culture Techniques
  • Department Of Defense
  • Diseases And Disorders
  • Gene Expression
  • Immune System
  • Medical Personnel
  • Multiple Sclerosis
  • Neurodegeneration
  • Pregnancy
  • Professional Development
  • Proteins
  • Standards
  • Stem Cells
  • Students
  • Technology Transfer

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry