Potential Genetic Markers for Susceptibility to Osteoarthritis and Rheumatoid Arthritis
Abstract
Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common arthritic disorders. OA is more frequent than RA, not only in the US general population, but also in the US military. The arthritic disorders along with musculoskeletal (MSK) injuries are the most common reasons for exit from military service. Together, they impose a major healthcare burden not only on the Department of Defense while the service members remain active, but also on the Department of Veterans Affairs once they leave. The fundamental determinants of predisposition to MSK disorders such as OA and RA are genetic, but such factors as nutrition, lifestyle, activity, and physical fitness are also players. Among genetic variations, the most frequent are single nucleotide polymorphisms (SNPs), with nearly 90 million identified in the human population. Most SNPs have no pathologic effects, but some do. The pathogenic SNPs and other genetic variations exert their pathologic effects by changing the activities of genes and their products (RNA, proteins), e.g., up- or down-regulating the activities of genes, or outright disrupting the functions of RNAs or proteins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 16, 2022
- Accession Number
- AD1163744
Entities
People
- G. J. Chaudry
- Hui Xia
- Jamie L. Myers
- Manuel Y. Caballero
- Sandra Valtier
- Tho Hua
Organizations
- 59th Medical Wing