Electroceutical Technology Against Bacterial Drug Resistance

Abstract

The objective of this work is to develop EDTlo and EDThi wound dressings against bacteria and fungal biofilm infections as MTEC Technology for prototype acceleration. Resilience, DoD). Two sp aims have been proposed: Aim 1. Specific Aim 1. To determine the ability of optimized electroceutical EDT dressings to eliminate mixed species, multi-drug resistant infection in an in vitro assay and porcine burn infection model. Aim 2. . Test whether wound closure in a pair-matched setting is improved using optimized EDT treatment compared to standard of care (SoC) in biofilm/MDR-infected porcine burn wounds. Aim 3. To determine the ability of optimized electroceutical EDT dressings to eliminate Candida albicans infection: Aim 3a. An in vitro biofilm assay and Aim 3b. In a porcine burn infection model.

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Document Details

Document Type
Technical Report
Publication Date
Oct 25, 2021
Accession Number
AD1165153

Entities

People

  • Chandan K Sen
  • Gayle M. Gordillo
  • Mohamed E. Masry
  • Nandini Ghosh
  • Sashwati Roy
  • Savita Khanna

Organizations

  • Indiana University Bloomington

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Contracts
  • Data Analysis
  • Department Of Defense
  • Drug Resistance
  • Education
  • Electron Microscopes
  • Electron Microscopy
  • Governments
  • Infection
  • Medical Personnel
  • Microscopy
  • Procurement
  • Resistance
  • Scanning Electron Microscopes
  • Scanning Electron Microscopy
  • Subcutaneous Tissue

Fields of Study

  • Biology
  • Chemistry

Readers

  • Microbial Pathology
  • Surface Engineering/Surface Coating Technology.
  • Trauma or Military Medicine

Technology Areas

  • Biotechnology