Clarifying the Role Played by Microglia and Astrocyte Activation in Veterans with Gulf War Illness UsingPositron Emission Tomography (PET)
Abstract
The study objective is to assess whether veterans with GWI will show evidence of a chronic inflammatory process as measured by increased levels of astrocyte and microglial activation. We will determine the regionally specific pattern of astrocyte activation in 20 GW veterans. We will determine if there is regionally independence of the astrocyte activation from microglial activation and we will assess the utility of using FDG PET as a marker for activated astrocytes. We have continued to focus on obtaining appropriate approvals while working with institutions which are trying to re-open their in person research programs. This study will take place a Mass General Brigham Hospital and Boston University School of Medicine. We have a subcontract in place between these institutions for this study. We have worked with the IRB at Boston University and they are in the process of ceding review of this study to Mass General Brigham Hospitals IRB. We have IRB approval from Mass General Brigham Hospitals IRB. The BBRAIN study from which we will be recruiting is up and running with in person visits.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1165704
Entities
People
- Ronald Killiany
Organizations
- Boston University Medical Campus