Developing Clinically Relevant Models of Mucinous Ovarian Carcinoma for Testing Therapies

Abstract

This project aims to create patient-relevant models for mucinous ovarian cancer (MOC). Over the last year, we have begun PDX experiments, transplanting one MOC case subcutaneously (no growth after 6 months), intraperitoneally (growth observed within 2 months) and intrabursally (growth observed within 2 months). We continue to collect tissue, although the pace has slowed, likely due to COVID disruptions at two collection sites. Nonetheless we have received four new carcinomas and one borderline tumour in the last year. Two of the carcinomas have grown sustainably as organoid lines. No cell lines have yet been able to be derived.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1166354

Entities

People

  • Kylie Gorringe

Organizations

  • University of Melbourne

Tags

DTIC Thesaurus Topics

  • Australia
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Computer Communications
  • Department Of Defense
  • Electronic Mail
  • Internet
  • Maryland
  • Medical Personnel
  • Monitoring
  • Neoplasms
  • New Zealand
  • Organoids
  • Ovarian Cancer
  • Patent Applications
  • Professional Development
  • Students
  • Technology Transfer
  • Therapy

Readers

  • Oncology
  • Oncology (Cancer Research).
  • Systems Analysis and Design

Technology Areas

  • Biotechnology