Developing New Therapeutic Strategies for Malignant Peripheral Nerve Sheath Tumor by Interrupting Immunologic Tolerance

Abstract

Based on recent data from us and others using human clinical MPNST specimens, we seek validation inmouse models of a novel treatment paradigm that could lead to new clinical trials. Our approach is based onstimulating antitumor immunity using oncolytic virus infections combined with inhibitors ofimmunosuppression, including those targeting TGF (both directly and indirectly, through the Janus kinaseinhibitor Ruxolitinb) and T cell checkpoints.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2021
Accession Number
AD1166360

Entities

People

  • Timothy Cripe

Organizations

  • Nationwide Children's Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cells
  • Chemistry
  • Combination Therapy
  • Cytokines
  • Department Of Defense
  • Health Services
  • Immunity
  • Immunotherapy
  • Lymphocytes
  • Medical Personnel
  • Oncolytic Viruses
  • Peptides
  • Peripheral Nervous System
  • Proteins
  • T Lymphocytes
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).