Epigenetic Modulation of SOS1 Gene Promotes Breast Cancer Disparity by Altering Immune Landscape
Abstract
In the US, more than 40,000 breast cancer patients succumb to this disease every year. The age-adjusted breast cancer incidence in AA women is lower compared to CA women. However, the mortality rates of AA women were 29.5 while the rates of CA women were 20.8. Thus, the cancer death rate in AA females is 14 percent higher than in CA female. However, exact reasons to explain this racial disparity is still yet poorly understood. The goals of the current proposal are to find genetic and non-genetic factors that influence the disease process that is specific to AA women so that we can identify the exact target to treat and prevent the aggressive breast cancer in this population. We hypothesize that AA women with obesity develop aggressive breast cancer by upregulation of the gene called SOS1 gene through race/ethnic specific non-genetic control and also by tiny RNA called miR-483. We also hypothesize that our identified compound called taxifolin and its modified chemical (TF-10) selectively suppress the proposed pathway, thereby preventing lung metastasis of breast cancer. We will focus our next years effort on further clarification of the SOS1 function on racial disparity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2022
- Accession Number
- AD1166782
Entities
People
- Kounosuke Watabe
Organizations
- Wake Forest University